Synthesis and antifungal evaluation of pyrido [1, 2-a] indole-1, 4-diones and benzo [f] pyrido [1, 2-a] indole-6, 11-diones

…, JH Yoon, AL Song, HA Im, JY Kim, A Kim

Index: Ryu, Chung-Kyu; Yoon, Joo Hee; Song, Ae Li; Im, Hyun Ah; Kim, Ji Young; Kim, Aram Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 497 - 499

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Citation Number: 7

Abstract

Pyrido [1, 2-a] indole-1, 4-diones and benzo [f] pyrido [1, 2-a] indole-6, 11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido [1, 2-a] indole-1, 4-diones and benzo [f] pyrido [1, 2-a] indole-6, 11-diones would be potent antifungal agents.

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