Developments in Meyers' Lactamization Methodology: En Route to Bi (hetero) aryl Structures with Defined Axial Chirality

S Postikova, M Sabbah, D Wightman…

Index: Postikova, Svetlana; Sabbah, Mohamad; Wightman, Daniel; Nguyen, Ich Tuan; Sanselme, Morgane; Besson, Thierry; Briere, Jean-Francois; Oudeyer, Sylvain; Levacher, Vincent Journal of Organic Chemistry, 2013 , vol. 78, # 16 p. 8191 - 8197

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Citation Number: 12

Abstract

Highly atroposelective Meyers' lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo (di) azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.