Facile and convenient synthesis of functionalized propargylic alcohols and amines: an InBr 3–Et 3 N reagent system promotes the alkynylation of aldehydes and N, O- …
N Sakai, R Kanada, M Hirasawa, T Konakahara
Index: Sakai, Norio; Kanada, Reiko; Hirasawa, Maki; Konakahara, Takeo Tetrahedron, 2005 , vol. 61, # 39 p. 9298 - 9304
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Citation Number: 43
Abstract
The use of a novel InBr3–Et3N reagent system to promote the alkynylation of not only a variety of aromatic/heterocyclic or bulky aliphatic aldehydes but also N, O-or N, S-acetals is described. The use of N-silyl-N, O-acetals and 1-alkynes could lead to the direct production of primary propargylic amines in good yields.
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