Indium (III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component …
ZL Shen, SJ Ji, TP Loh
Index: Shen, Zhi-Liang; Ji, Shun-Jun; Loh, Teck-Peng Tetrahedron, 2008 , vol. 64, # 35 p. 8159 - 8163
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Citation Number: 59
Abstract
A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium (III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.
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