Enantioselective acylation of alcohols catalyzed by lipase QL from Alcaligenes sp.: a predictive active site model for lipase QL to identify the faster reacting enantiomer …

…, M Murata, R Tanaka, M Yano, K Hirose, Y Tobe

Index: Naemura; Murata; Tanaka; Yano; Hirose; Tobe Tetrahedron Asymmetry, 1996 , vol. 7, # 6 p. 1581 - 1584

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Citation Number: 34

Abstract

Lipase QL-catalyzed acylation of secondary alcohols using isopropenyl acetate as the acylating agent in diisopropyl ether gave preferentially the corresponding acetate with an R configuration. On the basis of the results, a predictive active site model for lipase QL is proposed for identifying which enantiomer of a secondary alcohol reacts faster in this reaction.

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