Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis
HN Bramson, J Corona, ST Davis…
Index: Cuny; Lichtenthaler; Jahn Chemische Berichte, 1981 , vol. 114, # 5 p. 1624 - 1635
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Citation Number: 232
Abstract
... Volume: Page: ... GlaxoSmithKline Inc., Five Moore Drive, Research Triangle Park, North Carolina 27709. J. Med ... 4-alkylisatin hydrazones 7 were prepared as shown in Scheme 2. Heck coupling of 4-iodoisatin with alkenes produced 4-alkenylisatins 5, which were ...
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