Tetrahedron letters

A novel, facile methodology for the synthesis of N, N′-bis (tert-butoxycarbonyl)-protected guanidines using polymer-supported carbodiimide

O Guisado, S Martı́nez, J Pastor

Index: Guisado, Olga; Martinez, Sonia; Pastor, Joaquin Tetrahedron Letters, 2002 , vol. 43, # 39 p. 7105 - 7109

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Citation Number: 25

Abstract

A novel methodology for the synthesis of guanidines from amines has been developed using polymer assisted synthesis, potentially allowing the preparation of series of compounds in a high throughput manner. The methodology comprises the use of polymer- supported carbodiimide as the activating agent for N, N′-bis (tert-butoxycarbonyl) thiourea with polymer-supported trisamine as a scavenger, followed by deprotection with ...