Synthesis and activity evaluation of phenylurea derivatives as potent antitumor agents

…, NN Du, YM Wang, WY He, EZ Jiang, SX Cheng…

Index: Song, Dan-Qing; Du, Na-Na; Wang, Yue-Ming; He, Wei-Ying; Jiang, En-Zhu; Cheng, Shi-Xiang; Wang, Yan-Xiang; Li, Ying-Hong; Wang, Yu-Ping; Li, Xin; Jiang, Jian-Dong Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 11 p. 3873 - 3878

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Citation Number: 18

Abstract

We have discovered several tubulin-active compounds in our previous studies. In the establishment of a compound library of small molecule weight tubulin ligands, 14 new N-3- haloacylaminophenyl-N′-(alkyl/aryl) urea analogs were designed and synthesized. The structure–activity relationship (SAR) analysis revealed that (i) the order of anticancer potency for the 3-haloacylamino chain was following–CH2Br>–CHBrCH3;(ii) the N′- ...