Tetrahedron

Synthesis of 4-functionalized aryl-3, 5-diacyl-1, 4-dihydropyridines

ML Bennasar, T Roca, M Monerris, C Juan, J Bosch

Index: Bennasar, M.-Lluisa; Roca, Tomas; Monerris, Manuel; Juan, Cecilia; Bosch, Joan Tetrahedron, 2002 , vol. 58, # 40 p. 8099 - 8106

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Citation Number: 23

Abstract

The valuable N-unsubstituted 4-aryl-3, 5-diacyl-1, 4-dihydropyridines 12b–f, bearing an electron-withdrawing substituent at the benzene ring, have been synthesized by the copper- mediated addition of functionalized arylmagnesium reagents 2b–f to N- benzhydrylpyridinium salt 9, followed by acylation with trichloroacetic anhydride and the subsequent haloform reaction and N-deprotection.