New streptozotocin analogs with improved antileukemic activity

AN Fujiwara, EM Acton, DW Henry

Index: Fujiwara,A.N. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 392 - 396

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Citation Number: 14

Abstract

Streptozotocin (1) is an antibiotic with antileukemic and diabetogenic activity in animals.'In human patients it has been used with success for the treatment of malignant insulinoma* and is being tested against the whole range of common tumor types. 3 Kidney damage is the most common and most severe of various toxic side ef-t This work was performed under the auspices of the Division of Cancer Treatment. National Cancer Institute, Sational Institutes ...