Lipase-catalysed resolution of cyclic cis-and trans-β-hydroxy esters

LM Levy, JR Dehli, V Gotor

Index: Levy, Laura M.; Dehli, Juan R.; Gotor, Vicente Tetrahedron Asymmetry, 2003 , vol. 14, # 14 p. 2053 - 2058

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Citation Number: 20

Abstract

Lipases A and B from Candida antarctica are shown to be highly efficient and complementary biocatalysts for the resolution of five-to seven-membered cyclic β-hydroxy esters by O-acylation. Using this procedure, all four stereoisomers of each one are obtained in enantiopure form and very high yields.