Decarboxylative formation of N-alkyl pyrroles from 4-hydroxyproline

I Deb, DJ Coiro, D Seidel

Index: Deb, Indubhusan; Coiro, Daniel J.; Seidel, Daniel Chemical Communications, 2011 , vol. 47, # 22 p. 6473 - 6475

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Citation Number: 25

Abstract

Pyrroles are ubiquitous as components of natural products 1 and medicinal drugs. 2 Due to their favorable electronic properties, pyrroles are also prime candidates for applications in materials research. 3 Although numerous methods for the synthesis of pyrroles exist, 4–6 there is still major interest in new methods that rapidly produce pyrroles in a single step starting from cheap and readily available materials. Here we report an approach that reliably furnishes N-alkyl ...