The Alkylation of Coumarin at C-3 of 4-Hydroxycoumarin
I Tabakovic, K Tabakovic, I Gaon
Index: Tabakovic, Ibro; Tabakovic, Katmerka; Gaon, Igor Organic Preparations and Procedures International, 1997 , vol. 29, # 2 p. 223 - 226
Full Text: HTML
Citation Number: 8
Abstract
Several important natural compounds have an alkyl chain at C-3 on 4-hydroxycoumarin.' Compounds comprising 4-hydroxycoumarin nucleus are reported to have anthelmintic, hypnotic, insecticidal, antifungal activities and anticoagulant effect. 2 In an attempt to synthesize 3-geranylcoumarin, which is one of the natural coumarins,'4-hydroxycoumarin was treated with geranyl bromide in the presence of K2C0,, and the desired product was ...
Related Articles:
Model studies for a molecular mechanism of action of oral anticoagulants
[Silverman, Richard B. Journal of the American Chemical Society, 1981 , vol. 103, # 13 p. 3910 - 3915]
[Dittmer, Donald C.; Li, Qun; Avilov, Dimitry V. Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4682 - 4686]
[Morris, Joel; Luke, George P.; Wishka, Donn G. Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3218 - 3220]
[Appendino, Giovanni; Cravotto, Giancarlo; Tagliapietra, Silvia; Ferraro, Stefano; Nano, Gian Mario; Palmisano, Giovanni Helvetica Chimica Acta, 1991 , vol. 74, # 7 p. 1451 - 1458]
[Dittmer, Donald C.; Li, Qun; Avilov, Dimitry V. Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4682 - 4686]