Solvent-free synthesis of quinolone derivatives
P Cernuchova, G Vo-Thanh, V Milata, A Loupy
Index: Cernuchova, Petra; Vo-Thanh, Giang; Milata, Viktor; Loupy, Andre Heterocycles, 2004 , vol. 64, p. 177 - 191
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Citation Number: 29
Abstract
Résumé/Abstract Quinolones can be prepared in a three step procedure from triethylorthoformate and activated methylene derivatives leading to alkoxymethylenemalonates followed by reaction with aromatic amines and finally a cyclization. All the reactions were carried out under solvent-free conditions possibly under microwave activation with benefits for the first step.
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