Molecular modeling of γ-lactam analogues of β-lactam antibacterial agents: synthesis and biological evaluation of selected penem and carbapenem analoques
NE Allen, DB Boyd, JB Campbell, JB Deeter, TK Elzey…
Index: Allen, Norris E.; Boyd, Donald B.; Campbell, Jack B.; Deeter, Jack B.; Elzey, Thomas K.; et al. Tetrahedron, 1989 , vol. 45, # 7 p. 1905 - 1928
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Citation Number: 53
Abstract
Computational chemistry made possible the prediction of the three-dimensional structures of γ-lactam analogues of penems and carbapenems before the analogues were made. Molecular superpositioning showed that these novel structures with a 7β-acylamino side- chain present the pharmacophoric groups in close spatial similarity to the groups in biologically active cephalosporin and penicillin antibiotics. This suggests that 8-oxo-7- ...
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