Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors

…, XD Wang, H Ouyang, P Yang, J He, YF Wang…

Index: Xiao, Zhu-Ping; Peng, Zhi-Yun; Dong, Jing-Jun; Deng, Rui-Cheng; Wang, Xu-Dong; Ouyang, Hui; Yang, Pan; He, Juan; Wang, Yuan-Feng; Zhu, Man; Peng, Xiao-Chun; Peng, Wan-Xi; Zhu, Hai-Liang European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 212 - 221

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Citation Number: 36

Abstract

Abstract Inhibition of urease results in Helicobacter pylori growth arrest in the stomach, promoting urease as promising targets for gastrointestinal ulcer therapy. Twenty hybrid derivatives of flavonoid scaffold and hydroxamic acid, β-hydroxy-β- phenylpropionylhydroxamic acids, were therefore synthesized and evaluated against H. pylori urease. Biological evaluation of these compounds showed improved urease ...