Potential hypoglycemic agents: 1, 3, 4-oxadiazoles and related compounds

JB O'Neal, H Rosen, PB Russell…

Index: O'Neal,J.B. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 617 - 626

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Citation Number: 40

Abstract

A4 number of thiadiazolc and oxadiazole derivatives were synthesized and evaluated for oral hvpoglycemir activitv. All of the compounds were tested by single dose administration in rats and/or dogs by the oral route. Most of the derivatives exhibited some degree of activity. 5- Cvclohexyl-2-(p-tolurnesul-fonamidoj-1, 3, 4-oxadiazole was fairly potent in both rats and dogs, and on daily administration in dogs prodiicrd and maintained n hrpoglycemia. Some ...