Organic letters

Arylations of Substituted Enamides by Aryl Iodides: Regio-and Stereoselective Synthesis of (Z)-β-Amido-β-Arylacrylates

Q Gou, B Deng, H Zhang, J Qin

Index: Gou, Quan; Deng, Bin; Zhang, Hongbin; Qin, Jun Organic Letters, 2013 , vol. 15, # 17 p. 4604 - 4607

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Citation Number: 11

Abstract

Palladium-catalyzed Heck arylation, one of the most useful reactions to construct carbon–carbon bonds, involves the coupling of aryl halides/pseudohalides with olefins.(1) Heck arylations were typically catalyzed by Pd(0) or Pd(II) with an added phosphine ligand and operating under a Pd(0)/Pd(II) catalytic cycle with the assistance of base to complete the cycle. In a program directed toward synthesis of enamides,(2) especially trisubstituted enamide ...