Heterogeneous rhodium-catalyzed hydrogenation conditions for the highly effective synthesis of 1, 3-oxazolidines from 1, 2-amino alcohols and nitriles
S Létinois, JC Dumur, F Hénin, J Muzart
Index: Letinois, Stephane; Dumur, Jean-Christophe; Henin, Francoise; Muzart, Jacques Tetrahedron Letters, 1998 , vol. 39, # 16 p. 2327 - 2330
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Citation Number: 6
Abstract
A procedure easily to carried out for the synthesis of 1, 3-oxazolidines in high yields using 1, 2-amino alcohols, nitriles, an atmospheric pressure of hydrogen and catalytic quantites of rhodium on carbon powder is presented. This reaction probably involves the semi- hydrogenation of the nitrile followed by condensation with the amino alcohol. The process may constitute the key step in a two-step sequence for reducing a nitrile into the ...
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