Palladium-Catalyzed C (sp3)–H Arylation of Diarylmethanes at Room Temperature: Synthesis of Triarylmethanes via Deprotonative-Cross-Coupling Processes

J Zhang, A Bellomo, AD Creamer…

Index: Zhang, Jiadi; Bellomo, Ana; Creamer, Andrea D.; Dreher, Spencer D.; Walsh, Patrick J. Journal of the American Chemical Society, 2012 , vol. 134, # 33 p. 13765 - 13772

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Citation Number: 94

Abstract

Although metal-catalyzed direct arylation reactions of non-or weakly acidic C–H bonds have recently received much attention, chemists have relied heavily on substrates with appropriately placed directing groups to steer reactivity. To date, examples of intermolecular arylation of unactivated C (sp3)–H bonds in the absence of a directing group remain scarce. We report herein the first general, high-yielding, and scalable method for palladium- ...

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