The Use of N, N-Dimethylformamide in the Carbon Disulfide Ring Closure of 4, 5-Diaminopyrimidines2

RW BALSIGER, AL FIKES, TP JOHNSTON…

Index: Balsiger,R.W. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 3386 - 3388

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Citation Number: 15

Abstract

An improved procedurtx for the preparation of purinc4thiols by the reaction of 4, 5- diaminopyrirnidines with carbon disiilfide in N,,+ r-dimethylformamide is described. Application of this procedure to 4, 5-dianiinopyrimidines containing a group in the 6-position susceptible to nucleophilic attack resulted in intramolecular displacement of this group by the intermediate dithiocarbamate anions to give thiazolo [5, 4-d] pyrimidine-2-thiols. The ...