New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU
VV Sureshbabu, HS Lalithamba, N Narendra…
Index: Sureshbabu, Vommina V.; Lalithamba; Narendra; Hemantha Organic and Biomolecular Chemistry, 2010 , vol. 8, # 4 p. 835 - 840
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Citation Number: 17
Abstract
Conversion of carboxylic acids into acid azides using peptide coupling agents, EDC and HBTU is described. The procedure is efficient, practical and applicable to a diverse range of carboxylic acids including N-protected amino acids. Using the same reagents, one-pot synthesis of ureas, dipeptidyl urea esters and carbamates from acids has also been achieved.
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