Synthesis of [[(naphthalenylmethoxy)-and-(quinolinylmethoxy) phenyl] amino] oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5- …

JH Musser, DM Kubrak, J Chang…

Index: Musser; Kubrak; Chang; Lewis Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1429 - 1435

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Citation Number: 18

Abstract

Methods. The hydrolysis of 3c was initiated by the injection of 25 pL of a ca. 2.0 XM solution of 3c in CH3CN into 5 mL of an appropriate buffer solution that had been incubating for sufficient time at (25.0* 0.1)“C. Aliquots of 10 pL were periodically removed and injected directly onto an HPLC column (p-Bondapak C-18 column, 1: l MeOH/H20 eluent, 1 mL/min, UV absorbance monitored at 250 nm). HPLC peaks for 4 (rt= 4.3 min) and its labile ...