Journal of Heterocyclic Chemistry

A novel synthesis of theophylline derivatives

F Yoneda, R Koga

Index: Yoneda, Fumio; Koga, Ryosuke Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 813 - 816

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Citation Number: 4

Abstract

Abstract Treatment of 6-amino-5-arylazo-1, 3-dimethyluracils with ethyl propiolate gave the corresponding Michael-type adducts, 5-arylazo-1, 3-dimethyl-6- ethoxycarbonylvinylaminouracils, which on treatment with a mixture of hydrochloric acid and acetic acid caused the acid-catalyzed rearrangement accompanied with rearrangement to give rise to the corresponding 8-anilinomethyltheophylline derivatives.