Enhanced activity of fluorinated quaternary ammonium surfactants against Pseudomonas aeruginosa

L Massi, F Guittard, R Levy, S Géribaldi

Index: Massi, Lionel; Guittard, Frederic; Levy, Richard; Geribaldi European Journal of Medicinal Chemistry, 2009 , vol. 44, # 4 p. 1615 - 1622

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Citation Number: 33

Abstract

A novel series of fluorinated quaternary bisammonium surfactants has been synthesized in view to optimize their antimicrobial activities against Pseudomonas aeruginosa. As compared with commercial references, most of the new surfactants synthesized exhibit an enhanced activity which is discussed as a function of the nature of the spacer group between the quaternized nitrogen atoms and of the nature of the connector function ...