The Journal of Organic Chemistry

A convenient procedure for the preparation of ethoxyacetylene and ethoxyethynyl carbinols

S Raucher, BL Bray

Index: Raucher, Stanley; Bray, Brian L. Journal of Organic Chemistry, 1987 , vol. 52, # 11 p. 2332 - 2333

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Citation Number: 21

Abstract

The use of ethoxyacetylene in organic synthesis is well-known." b The condensation of ketones or aldehydes with the anion of ethoxyacetylene yields carbinols, which may be converted to a,@-unsaturated esters, aldehydes, or carboxylic Ethoxyacetylene undergoes cycloaddition reactions with ketenes to form cyclobutenone ethem2g-'It has also been used as a coupling reagent in the synthesis of peptides2j and acid anhydrides. 2b Although ...