Synthesis and biological activity of N-aroyl-tetrahydro-γ-carbolines

…, R Millet, J Pommery, N Pommery, JP Henichart

Index: Bridoux, Alexandre; Millet, Regis; Pommery, Jean; Pommery, Nicole; Henichart, Jean-Pierre Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 11 p. 3910 - 3924

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Citation Number: 9

Abstract

Research on dual inhibitors of both 5-LOX and COXs gained interest due to the overexpressions of these enzymes during the malignant state of the evolution of prostate cancer. In order to take part in this research, new N-aroyl-tetrahydro-γ-carbolines issued from the modification of Indomethacin have been synthesised. As for the NSAIDs, the compounds have been tested for their activity against COX1, COX2 plus against 5-LOX ...