S-Homoadenosyl-l-cysteine and S-Homoadenosyl-l-homocysteine. Synthesis and Binding Studies of Non-Hydrolyzed Substrate Analogues with S-Adenosyl-l- …
RW Miles, LPC Nielsen, GJ Ewing, D Yin…
Index: Miles, Robert W.; Nielsen, Lars P. C.; Ewing, Gregory J.; Yin, Daniel; Borchardt, Ronald T.; Robins, Morris J. Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8258 - 8260
Full Text: HTML
Citation Number: 14
Abstract
Treatment of homoadenosine [9-(5-deoxy-β-d-ribo-hexofuranosyl) adenine] with thionyl chloride and pyridine in acetonitrile gave 6'-chloro-6'-deoxyhomoadenosine, which underwent nucleophilic displacement with l-cysteine or l-homocysteine to give homologated analogues of S-adenosyl-l-homocysteine. Each amino acid in aqueous sodium hydroxide at 60° C gave excellent conversion from the chloronucleoside, and adsorption on Amberlite ...
Related Articles:
[Robins; Guo; Wnuk Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3637 - 3638]
[Robins; Guo; Wnuk Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3637 - 3638]
[Robins; Guo; Wnuk Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3637 - 3638]
Darstellung und Konformationszuordnung einiger 5′??homologer Adenosinderivate
[Hollmann, Juergen; Schlimme, Eckhard Liebigs Annalen der Chemie, 1984 , # 1 p. 98 - 107]
5′-Homoaristeromycin. Synthesis and antiviral activity against orthopox viruses
[Yang, Minmin; Schneller, Stewart W. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 149 - 151]