Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes

…, J Wenzel, M Trujillo, M López, J Joseph…

Index: Bartesaghi, Silvina; Wenzel, Jorge; Trujillo, Madia; Lopez, Marcos; Joseph, Joy; Kalyanaraman, Balaraman; Radi, Rafael Chemical Research in Toxicology, 2010 , vol. 23, # 4 p. 821 - 835

Full Text: HTML

Citation Number: 48

Abstract

Protein tyrosine dimerization and nitration by biologically relevant oxidants usually depend on the intermediate formation of tyrosyl radical (• Tyr). In the case of tyrosine oxidation in proteins associated with hydrophobic biocompartments, the participation of unsaturated fatty acids in the process must be considered since they typically constitute preferential targets for the initial oxidative attack. Thus, we postulate that lipid-derived radicals mediate the one- ...