P-Dimethoxy-substituted trans-octahydrobenzo [f]-and-[g] quinolines: synthesis and assessment of dopaminergic agonist effects

…, VED Amoo, JP Long, RK Bhatnagar…

Index: Cannon; Amoo; Long; Bhatnagar; Flynn Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2529 - 2534

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Citation Number: 20

Abstract

The Nn-propyl homologues of the title compounds were prepared for further assessment of the ability of the" p-dimethoxy" moiety to confer dopaminergic agonism upon a variety of ring systems. Both the angularly and the linearly annulated trans-benzoquinoline ring derivatives displayed prominent DA2 dopaminergic effects on the peripheral sympathetic nerve terminal and displayed postjunctional dopamine receptor agonist properties in the striatum. It is ...