Silylations with bis (trimethylsilyl) acetamide, a highly reactive silyl donor

JF Klebe, H Finkbeiner, DM White

Index: Klebe,J.F. et al. Journal of the American Chemical Society, 1966 , vol. 88, p. 3390 - 3395

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Citation Number: 368

Abstract

Abstract: Silyl-proton exchange reactions with bis (trimethylsily1) acetamide proceed rapidly and quantitatively under mild conditions. The preparative silylation of amides, ureas, and amino acids, as well as hindered phenols, carboxylic acids, and enols, is described. Examples of silylation as a protective measure and a means of preparing reactive intermediates are included. he quantitative conversion of organic compounds T to stable, ...