Journal of medicinal chemistry

Antitumor septacidin analogs

EM Acton, KJ Ryan, AE Luetzow

Index: Acton,E.M. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 1362 - 1371

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Citation Number: 19

Abstract

23, X= N,; R'= Bz 24, X= N,; R'= H 25, X= NH,; R'= H temperature. Catalytic hydrogenation afforded the weakly basic glycosylamine 19a, which was not isolated but was condensed7 immediately with 4-amino-6-chloro-5-nitro-pyrimidine to give 20a. Hydrogenation and crystallization afforded the 4, 5-diaminopyrimidine 21a as the chromatographically homogeneous@-anomer in 74% yield. Diamine 21a was unexpectedly accompanied by ...