Bioorganic & medicinal chemistry letters

Synthesis and evaluation of novel 1, 4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents

VK Tandon, RV Singh, DB Yadav

Index: Tandon, Vishnu K.; Singh, Ravindra V.; Yadav, Dharmendra B. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 11 p. 2901 - 2904

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Citation Number: 70

Abstract

The synthesis and evaluation of some 2-substituted-1, 4-naphthoquinones 2, S-(1, 4- naphthoquinon-2-yl)-mercaptoalkanoic acid amides 4, related benzoquinone and naphthoquinone derivatives 6–9 and 2, 3-disubstituted 1, 4-naphthoquinones 10–11 were carried out. The antifungal, antibacterial, antiviral and anticancer activities were determined by using the standard assay. The results show that compounds 2b and 10a showed in ...