Synthesis of an analog of camptothecin by a general method

RE Lyle, JA Bristol, MJ Kane…

Index: Lyle,R.E. et al. Journal of Organic Chemistry, 1973 , vol. 38, p. 3268 - 3271

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Citation Number: 13

Abstract

The introduction of the or-hydroxybutyrate chain on the 4 position of 0-picoline via the 4- lithio derivative gave 7. The oxidation of the 3-methyl substituent required for lactone formation between the substituents on the 3 and 4 positions of 7 to give 14 could only be accomplished after introducing a chloro group adjacent to the ring nitrogen. The quaternisation of 2 and the hydrolysis of the aryl-a-chloro substituent completed the ...