Decomposition and Stabilization of Drugs. XIX. Kinetic Studies on the Hydrolysis of Bencyclane Fumarate

K KIGASAWA, H SHIMIZU, S HAYASHIDA…

Index: Kigasawa; Shimizu; Hayashida; Fujino Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1398 - 1402

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Citation Number: 4

Abstract

Bencyclane fumarate (I) was decomposed in aqueous buffer solution from pH 1.2 to 6.3 in order to examine its stability and mechanism of hydrolysis. It was found that I was hydrolyzed with pseudo first-order kinetics, and the pH-rate profile was a straight line of slope-1. The activation energy (Ea) was calculated to be 33.0 kcal/mol from Arrhenius plots. Further examination of the decomposition mechanism through kinetic analysis suggested a new ...