Carbohydrate biguanides as potential hypoglycemic agents.

…, RW Tuman, CS Marchione, AD Jordan Jr…

Index: Reitz; Tuman; Marchione; Jordan Jr.; Bowden; Maryanoff Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2110 - 2116

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Citation Number: 67

Abstract

A series of monosaccharides containing a biguanide functionality was prepared and evaluated for hypoglycemic activity. Among the analogues prepared were those involving Dglucose substituted on the 6-or 1-position (19 and 24), Dgalactcae substituted on the 6- position (7), and D-arabinose (31). The target compounds were evaluated in a modified rat glucose-tolerance test (oral glucose load/oral drug, 100 mg/kg). Compounds 8 [6- ...