The Journal of Organic Chemistry

The Synthesis of 4-Aminoisoxazolo [5, 4-d] pyrimidines1

EC Taylor, EE Garcia

Index: Taylor,E.C.; Garcia,E.E. Journal of Organic Chemistry, 1964 , vol. 29, p. 2116 - 2120

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Citation Number: 33

Abstract

A number of derivatives of isoxazolo [5, 4-d] pyrimidine have been prepared as potential purine antagonists. Condensation of hydroxylamine with methylethoxymethylenemalononitrile, ethylethoxymethylenemalono-nitrile, and phenylmethoxymethylenemalononitrile gave a series of 3-substituted 4-cyano-5- aminoisoxazoles which, upon reaction with ethyl orthoformate-acetic anhydride, followed ...