Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica

L Zou, RB Zheng, TL Lowary

Index: Zou, Lu; Zheng, Ruixiang Blake; Lowary, Todd L. Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1219 - 1226

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Citation Number: 5

Abstract

Abstract A series of methoxy and deoxy derivatives of mannopyranose-1-phosphate (Manp- 1P) were chemically synthesized, and their ability to be converted into the corresponding guanosine diphosphate mannopyranose (GDP-Manp) analogues by a pyrophosphorylase (GDP-ManPP) from Salmonella enterica was studied. Evaluation of methoxy analogues demonstrated that GDP-ManPP is intolerant of bulky substituents at the C-2, C-3, and C-4 ...