Bromination of Some Anilinopyrimidines

AP Phillips, A Maggiolo

Index: Phillips; Maggiolo Journal of the American Chemical Society, 1952 , vol. 74, p. 3922

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Abstract

In order to determitle the poirit of preferential attack in electrophilic substitution reactions, the bromination of several 2-and 4-anilinopyrimidines has been studied When the pyrimidine is activated by two amino groups (including the anilino) substitution is favored at the 5-position of the pyrimidine When methyls are the only pyrimidine substituents except for the anilino, the anilino nitrogen appears to direct electrophilic attack with about equal facility to the ...