Synthesis and antiinflammatory activity of metabolites of 4-(3-dimethylaminopropionyl)-1, 2-dimethoxybenzene

…, PG Gaidyalis, ÉB Udrenaite, LK Labanauskas…

Index: Daukshas, V. K.; Gaidyalis, P. G.; Udrenaite, E. B.; Labanauskas, L. K.; Gumbaragite, L. F. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 10 p. 763 - 766 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 10 p. 56 - 58

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Abstract

The hydrochlorides of the aminoketones (II) and (III) were synthesized by the Mannich reaction using the interaction of the corresponding ketones (V) and (VI) with the formaldehyde and dimethylamine hydrochloride in the solution of 2-propanol. The aminoketone (VIII) was obtained by the action of methylamine on the chloroketone (VII) in benzene solution, and the reduction of the aminoketone (I) with sodium borohydride in ...