Thiazole analogs of pyridoxine

LH Conover, DS Tarbell

Index: Conover; Tarbell Journal of the American Chemical Society, 1950 , vol. 72, p. 5221,5224

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Citation Number: 28

Abstract

The synthesis of thiazole2 and pyrimidine3 analogs of pyridoxine (I) was undertaken originally to make the compounds available for antimalarial tests4 The present paper reports the preparation of 2-methyl-4, 5-bis-(hydroxymethyl)-thiazole (11), and describes numerous experiments designed to lead to the corresponding 2-hydroxy compound (111).