Trifluoromethylation of heterocumulenes with trimethyl (trifluoromethyl) silane in the presence of fluoride ions: synthesis of trifluoroacetamides and …

…, YL Yagupolskii, NV Petukh, W Tyrra, D Naumann

Index: Kirij, Nataliya V.; Yagupolskii, Yurii L.; Petukh, Nataliya V.; Tyrra, Wieland; Naumann, Dieter Tetrahedron Letters, 2001 , vol. 42, # 46 p. 8181 - 8183

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Citation Number: 12

Abstract

Trimethyl(trifluoromethyl)silane, Me 3 SiCF 3 , at present time is the most easily accessible and convenient source of the trifluoromethyl anion. 1. and 2. The importance of this reagent in fluorine chemistry might be compared with that of Grignard reagents introduced in organic chemistry about 150 years ago. Good storage and hydrolytic stability, ease in dosation and usability over a wide range of reaction conditions (in polar and nonpolar solvents, at different ...