Tetrahedron

An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect

N Kaval, B Halasz-Dajka, G Vo-Thanh, W Dehaen…

Index: Kaval, Nadya; Halasz-Dajka, Beata; Vo-Thanh, Giang; Dehaen, Wim; Van Der Eycken, Johan; Matyus, Peter; Loupy, Andre; Van Der Eycken, Erik Tetrahedron, 2005 , vol. 61, # 38 p. 9052 - 9057

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Citation Number: 54

Abstract

Significant improvements in the synthesis of pyrido-fused heterocycles were observed when performing the reaction under solvent-free conditions, applying the tert-amino effect as the key ring closure methodology. An unexpected cyclization of ortho-(1′-azacycloalkyl) benzaldehydes has been studied in water and on solid support.