Tetrahedron letters

Synthesis of L-β-(isoxazolin-5-one-2-yl)-alanine: a novel method for the synthesis of N-substituted 3, 4-unsubstituted isoxazolin-5-ones

JE Baldwin, RM Adlington, DJ Birch

Index: Baldwin, Jack E.; Adlington, Robert M.; Birch, David J. Tetrahedron Letters, 1985 , vol. 26, # 48 p. 5931 - 5934

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Citation Number: 21

Abstract

Abstract A mild new general method for the synthesis of the isoxazolin-5-one-2-yl ring system (4) via a favoured 5-endo-dig cyclisation is described; this methodology has been successfully applied for the first chemical enantio-efficient synthesis of Full-size image (< 1 K)