Insight into technetium amidoxime complex: Oxo technetium (v) complex of n-substituted benzamidoxime as new basic structure for molecular imaging

…, T Uehara, Y Tooyama, H Braband, R Alberto…

Index: Thipyapong, Khajadpai; Uehara, Tomoya; Tooyama, Yuji; Braband, Henrik; Alberto, Roger; Arano, Yasushi Inorganic Chemistry, 2011 , vol. 50, # 3 p. 992 - 998

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Citation Number: 10

Abstract

In search of benzamidoxime (BHam) derivatives that provide a single 99m Tc-labeled compound of high in vivo stability, we synthesized three N-alkyl compounds of benzamidoxime (BHam) ligand. They provided a single 99m Tc-labeled compound by ligand exchange reaction of 99m Tc-glucoheptonate in high radiochemical yields (over 95% at MBHam concentration of 1 × 10 −5 M). 99m Tc-N-methyl benzamidoxime ( 99m Tc-MBHam) showed higher stability than ...