Synthesis and renal vasodilator activity of 2-chlorodopamine and N-substituted derivatives

…, MB Zimmerman, MA Wenger, LW Emmert

Index: McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W. Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590

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Citation Number: 11

Abstract

A four-step synthesis of 2-chlorodopamine (2b) is presented as well as methods for the syntheses of the N-methyl, ethyl, and n-propyl analogues (2c-e). Compounds 2b and 2c were essentially equipotent to dopamine for increasing renal blood flow in anesthetized dogs that had been treated with the a-adrenergic antagonist phenoxybenzamine. The increases in renal blood flow were blocked by the DA1 antagonist (R)-(+)-8-chloro-2, 3, 4, ...