Cyclic-tri (N-methyl-meta-benzamide) s: substituent effects on the bowl-shaped conformation in the crystal and solution states

…, M Matsumura, K Yamaguchi, H Kagechika, A Tanatani

Index: Kakuta, Hiroki; Azumaya, Isao; Masu, Hyuma; Matsumura, Mio; Yamaguchi, Kentaro; Kagechika, Hiroyuki; Tanatani, Aya Tetrahedron, 2010 , vol. 66, # 42 p. 8254 - 8260

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Citation Number: 9

Abstract

Cyclic trimers of 3-(N-alkylamino) benzoic acid (calix [3] amides) with various substituents at the meta position of the phenyl rings were synthesized and the effects of the substituents on the crystal structures and energy profiles in solution were examined. The calixamides existed in a syn conformation in the crystal state, and this was also the major conformation in solution, especially in polar solvents. The energy barrier between syn and anti conformers ...