The Journal of Organic Chemistry

The synthesis of indolizines: the reaction of. alpha.-halo pyridinium salts with. beta.-dicarbonyl species

RA Nugent, M Murphy

Index: Nugent, Richard A.; Murphy, Megan Journal of Organic Chemistry, 1987 , vol. 52, # 11 p. 2206 - 2208

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Citation Number: 38

Abstract

Results Halopyridinium salts 3 were prepared from 2-bromo (or 2-chloro) pyridine and an appropriate a-halo ketone or ester by heating them neat at 120 OC for 1 hour and then continuing the reaction at 80" C for 22 h or diluting the mixture with toluene and heating at reflux for 16 h. The resulting solid was collected by filtration and recrystallized from EtOH.