RuCl2 (dmso) 4 Catalyzes the Solvent??Free Indirect Friedländer Synthesis of Polysubstituted Quinolines from Alcohols
R Martinez, DJ Ramon, M Yus
Index: Martinez, Ricardo; Ramon, Diego J.; Yus, Miguel European Journal of Organic Chemistry, 2007 , # 10 p. 1599 - 1605
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Citation Number: 28
Abstract
Abstract The first synthesis of polysubstituted quinoline derivatives from aromatic or aliphatic alcohols with RuCl 2 (dmso) 4 as catalyst under solvent-free conditions is described. The reaction involves the in situ oxidation of alcohols to the corresponding carbonyl compounds through a hydrogen-transfer, followed by a Friedländer annulation process. The whole process is a mild, efficient, selective, and high-yielding single-step procedure.(© Wiley- ...
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