Identification, synthesis and pharmacological activity of moxonidine metabolites

…, MM He, BA Czeskis, KM Zimmerman, U Roettig…

Index: Wirth, David D; He, Minxia M; Czeskis, Boris A; Zimmerman, Karen M; Roettig, Ulrike; Stenzel, Wolfgang; Steinberg, Mitchell I European Journal of Medicinal Chemistry, 2002 , vol. 37, # 1 p. 23 - 34

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Citation Number: 3

Abstract

The metabolism of moxonidine, 4-chloro-N-(4, 5-dihydro-1H-imidazol-2-yl)-6-methoxy-2- methyl-5-pyrimidinamine, LY326869, in rats, mice, dogs, and humans has been examined. At least 17 metabolites were identified or tentatively identified in the different species by HPLC, LC/MS and LC/MS/MS. The identities of seven of the major metabolites have been verified by independent synthesis. The metabolites are generally derived from oxidation ...